Stem Cell

Rats had their spinal cords hemisected at two separated levels—the right side at T7 and the left side at T12—and received a single intravenous dose of bone-marrow-derived mesenchymal stem cells the day after injury. At 28 days the motor score was 12.2 versus 5.4. The nerve pathways drawn from nine hours of 7-tesla MRI on the excised cords had built a detour to the outside at the rostral lesion. At the caudal lesion, however, what stood out was not a lateral detour but a route crossing the midline to the opposite side. Dr. Exotaro reads a preclinical study.

A phase 3 trial in ALS of autologous mesenchymal stem cells induced to secrete high levels of neurotrophic factors (NurOwn). The primary endpoint was not met (33% vs 28%, OR=1.33, P=.45). The signal in the less-impaired subgroup was not statistically significant and is only hypothesis-generating, yet the CSF biomarkers showed a clear biological effect. A piece for reading expectation and reality apart.

Testicular cancer mainly arises in men aged 15 to 35 and is regarded as one of the most curable solid tumors. But this review tackles refractory forms using cell therapy.

Stem cell research has produced revolutionary results in biology and medicine. This website aims to provide a comprehensive understanding of stem cell clinical science.

Stem cell therapy is attracting attention as a treatment that may broaden the options for diseases that previously had none. The influence of iPS Nobel laureate Dr. Shinya Yamanaka is significant.