THE EXOSOME FRONTIER · The frontier of extracellular-vesicle research

Fighting disease
with the power of cells.

The global frontier of exosome & extracellular-vesicle (EV) research, read in depth and shared in six languages. Close readings of notable papers, every week.

69+

papers analyzed

6

languages

∞

cellular potential

LIVE-CELL IMAGING

The green puncta are intracellular exosomes (extracellular vesicles). Live-cell imaging of vesicle biogenesis and transport inside living MSCs (mesenchymal stem cells).

// LATEST RESEARCH

Latest paper analyses

Continuous Infusion of Human MSC-Derived Exosomes (sEV) Enhances Motor Recovery in Spinal Cord Injury: How You Deliver Them Matters More Than the Total Dose

MSC-derived small extracellular vesicles (sEV) were given IV to spinal cord injury rats. At the same total dose, continuous infusion enhanced motor recovery more than daily injection.

解説を読む →

Accelerating the Clinical Translation of Extracellular Vesicles (EVs): The Work of ISEV-TRA and Future Prospects

Extracellular vesicles (EVs) are key mediators of intercellular communication with broad application across biomedicine, veterinary medicine, cosmetics, agriculture, and the environment.

解説を読む →

The Vicious Cycle of Prostate Cancer Bone Metastasis: Molecular Mechanisms by Which Cancerized Osteoclast-Derived Exosomes Drive Inflammatory Osteolysis and Tumor Progression

Bone metastasis of prostate cancer (PCa) markedly worsens prognosis, with a 5-year survival rate of only 30%, and features a complex mix of osteolytic and osteoblastic lesions.

解説を読む →

Molecular Mechanism by Which Cortical Actin Depolymerization in 3D Culture Enhances MSC-Derived Exosome Secretion and Therapeutic Efficacy

This study aimed to elucidate, at the molecular level, the mechanism by which 3D culture of mesenchymal stem cells (MSCs) promotes secretion of extracellular vesicles (sEVs) compared with 2D culture.

解説を読む →

Bispecific Exosome Therapy: An Innovative Approach to Immune Checkpoint Inhibitor-Resistant Melanoma Metastasis

This study focuses on developing an inhalable bispecific exosome-activated T cell (BEAT) system to treat metastatic melanoma resistant to immune checkpoint inhibitors (ICIs).

解説を読む →

Astrocyte-Derived Exosome-Mediated Transport of Rps6 Promotes Local Translation and Synaptic Function in Alzheimer's Disease Model Neurons

This study elucidates how astrocyte-secreted exosomes (EVs) regulate local translation in neuronal axons and improve synaptic function in an experimental model of Alzheimer's disease (AD).

解説を読む →

Continuous Infusion of Human MSC-Derived Exosomes (sEV) Enhances Motor Recovery in Spinal Cord Injury: How You Deliver Them Matters More Than the Total Dose

MSC-derived small extracellular vesicles (sEV) were given IV to spinal cord injury rats. At the same total dose, continuous infusion enhanced motor recovery more than daily injection.

解説を読む →

Accelerating the Clinical Translation of Extracellular Vesicles (EVs): The Work of ISEV-TRA and Future Prospects

Extracellular vesicles (EVs) are key mediators of intercellular communication with broad application across biomedicine, veterinary medicine, cosmetics, agriculture, and the environment.

解説を読む →

The Vicious Cycle of Prostate Cancer Bone Metastasis: Molecular Mechanisms by Which Cancerized Osteoclast-Derived Exosomes Drive Inflammatory Osteolysis and Tumor Progression

Bone metastasis of prostate cancer (PCa) markedly worsens prognosis, with a 5-year survival rate of only 30%, and features a complex mix of osteolytic and osteoblastic lesions.

解説を読む →

Molecular Mechanism by Which Cortical Actin Depolymerization in 3D Culture Enhances MSC-Derived Exosome Secretion and Therapeutic Efficacy

This study aimed to elucidate, at the molecular level, the mechanism by which 3D culture of mesenchymal stem cells (MSCs) promotes secretion of extracellular vesicles (sEVs) compared with 2D culture.

解説を読む →

Bispecific Exosome Therapy: An Innovative Approach to Immune Checkpoint Inhibitor-Resistant Melanoma Metastasis

This study focuses on developing an inhalable bispecific exosome-activated T cell (BEAT) system to treat metastatic melanoma resistant to immune checkpoint inhibitors (ICIs).

解説を読む →

Astrocyte-Derived Exosome-Mediated Transport of Rps6 Promotes Local Translation and Synaptic Function in Alzheimer's Disease Model Neurons

This study elucidates how astrocyte-secreted exosomes (EVs) regulate local translation in neuronal axons and improve synaptic function in an experimental model of Alzheimer's disease (AD).

解説を読む →

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抜いた髪の毛が“再生医療の宝”に——毛包に眠る幹細胞とエクソソーム最前線【前臨床研究】毛包由来幹細胞書き出し

慢性期脊髄損傷に光　点滴は回数がカギ骨髄間葉系幹細胞で歩行が伸びる？

【脊髄損傷】MSC点滴で“バイパス”が太る―赤核脊髄路を可視化

脊髄損傷本線は切れても動きは戻る骨髄間葉系幹細胞が開く回復のう回路

もの忘れが治る？幹細胞が脳の血管を修理する時代

一回の幹細胞点滴で寿命が伸びる！？　論文解説

慢性期脳損傷に挑む！骨髄間葉系幹細胞治療の新しい可能性

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// ALL ARTICLES

All articles

Continuous Infusion of Human MSC-Derived Exosomes (sEV) Enhances Motor Recovery in Spinal Cord Injury: How You Deliver Them Matters More Than the Total Dose

MSC-derived small extracellular vesicles (sEV) were given IV to spinal cord injury rats. At the same total dose, continuous infusion enhanced motor recovery more than daily injection.

解説を読む →

Accelerating the Clinical Translation of Extracellular Vesicles (EVs): The Work of ISEV-TRA and Future Prospects

Extracellular vesicles (EVs) are key mediators of intercellular communication with broad application across biomedicine, veterinary medicine, cosmetics, agriculture, and the environment.

解説を読む →

The Vicious Cycle of Prostate Cancer Bone Metastasis: Molecular Mechanisms by Which Cancerized Osteoclast-Derived Exosomes Drive Inflammatory Osteolysis and Tumor Progression

Bone metastasis of prostate cancer (PCa) markedly worsens prognosis, with a 5-year survival rate of only 30%, and features a complex mix of osteolytic and osteoblastic lesions.

解説を読む →

Molecular Mechanism by Which Cortical Actin Depolymerization in 3D Culture Enhances MSC-Derived Exosome Secretion and Therapeutic Efficacy

This study aimed to elucidate, at the molecular level, the mechanism by which 3D culture of mesenchymal stem cells (MSCs) promotes secretion of extracellular vesicles (sEVs) compared with 2D culture.

解説を読む →

Bispecific Exosome Therapy: An Innovative Approach to Immune Checkpoint Inhibitor-Resistant Melanoma Metastasis

This study focuses on developing an inhalable bispecific exosome-activated T cell (BEAT) system to treat metastatic melanoma resistant to immune checkpoint inhibitors (ICIs).

解説を読む →

Astrocyte-Derived Exosome-Mediated Transport of Rps6 Promotes Local Translation and Synaptic Function in Alzheimer's Disease Model Neurons

This study elucidates how astrocyte-secreted exosomes (EVs) regulate local translation in neuronal axons and improve synaptic function in an experimental model of Alzheimer's disease (AD).

解説を読む →

The Role of Extracellular Matrix Degradation in Supporting Synaptic Plasticity During Brain Development

Using the zebrafish brain, this study reveals the crucial role that degradation of the extracellular matrix (ECM) plays in synaptic plasticity during brain development.

解説を読む →

GLP-1 Receptor Agonists: A New Hope for Alzheimer's Disease Treatment? Mechanisms and Clinical Significance from Multiple Perspectives

GLP-1 receptor agonists (GLP-1RA), approved for type 2 diabetes (T2D), obesity, and cardiovascular disease, are now drawing attention as potential therapies for Alzheimer's disease (AD).

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NAC: A Multifaceted Regulator of Nascent Polypeptide Chains That Senses the Ribosomal Tunnel and Controls Chaperone Function

This study reveals that the nascent polypeptide-associated complex (NAC) is a multifaceted regulator coordinating translation elongation, co-translational folding, and organelle targeting.

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Chemotherapy Remodels Cardiac Macrophages: A New Path to Cardioprotection

This study reveals that DNA-damaging chemotherapy dramatically alters the composition and function of cardiac-resident macrophages, with monocyte-derived macrophages conferring cardioprotection.

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[Research Note] Network Analysis of 5 Key miRNAs Controlling Macrophages and Their "Converging Target Proteins"

In macrophage (RAW264.7, THP-1, Kupffer cell) phenotype control, which proteins do specific miRNAs target, and what fate (inflammation, M1/M2 polarization, pyroptosis) do they ultimately drive?

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Microglial TGFβ signaling in the spinal dorsal column maintains resilience to age-associated myelin degeneration

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration, published in Nature Neuroscience.

解説を読む →

Blood Biomarkers of Multimorbidity: Probing the Mechanisms of Aging Through Shared and Specific Features

This study identifies blood biomarkers of multimorbidity in older adults and clarifies their shared and specific features, linking 54 biomarkers to multimorbidity indicators in two cohorts.

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A Newcomer Macrophage Hiding in Exocrine Glands, the "Adenophage": How ILC2s and GM-CSF Weave the Secret of Maintaining Tissue Function

This study reveals a previously unknown macrophage population, the "adenophages," in exocrine glands such as the salivary glands, maintained by GM-CSF from group 2 innate lymphoid cells (ILC2s).

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Stop the Cell's "Rusting Death"! How Ferroptosis Inhibitors Open a New Frontier in Treating Intractable Diseases

Why does this research matter? Our bodies are made up of tens of trillions of cells. At the end of their lifespan or when infected, these cells carry a built-in mechanism to end their own lives.

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The Future of Testicular Cancer Treatment: A New Strategy in Which Immune Cells and Stem Cells Break Through Refractory Cancer

Testicular cancer mainly arises in men aged 15 to 35 and is regarded as one of the most curable solid tumors. But this review tackles refractory forms using cell therapy.

解説を読む →

Extracellular Vesicles

The Secret of Steering the Brain's Regeneration Factory: How L-Myc and the Cell's Courier Service (EVs) Unlock the Diversity of Neural Stem Cells

The brain barely regenerates after injury. Using single-cell analysis, this work reveals how the gene L-Myc and extracellular vesicles (EVs) drive the diversity of neural stem cells.

解説を読む →

Hope for Liver Cancer Treatment? The Remarkable Power of Umbilical Cord Stem Cells

A new treatment is anticipated for hepatocellular carcinoma (HCC), one of the most refractory cancers: cell therapy using umbilical cord-derived mesenchymal stem cells (UC-MSCs).

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Toward the dream of skin regeneration! The future of wound treatment opened up by stem cells and exosomes

Treating refractory wounds and severe burns is a major challenge in modern medicine. This paper reviews the potential of mesenchymal stem cells (MSCs) and their exosomes for skin regeneration.

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The Power of Dental Stem Cells! The Potential of "Exosomes" to Heal Spinal Cord Injury

Spinal cord injury (SCI) leaves severe sequelae, but a groundbreaking treatment has now been proposed: therapy using tiny capsules called exosomes (DPSC-Exos) secreted by dental stem cells (DPSC).

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See all articles (69) →