2026-10-08
Counting mRNA-Carrying Lipid Nanoparticles One at a Time — The Average Load Was 2.8 mRNA Molecules, and 8 Out of 10 Particles Were Running 'Empty'
The 'encapsulation efficiency 94%' on an LNP spec sheet counts mRNA, not particles. A 2022 Nature Communications paper counted one particle at a time: mean 2.80 copies, mode 2, 77% carrying none.
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