Treating refractory wounds and severe burns is a major challenge in modern medicine. This paper reviews the potential application of mesenchymal stem cells (MSCs), which have attracted attention in the field of tissue engineering, and the exosomes they secrete, for skin regeneration.
MSCs are multifunctional cells that promote the repair of injured tissue, but in recent years it has become clear that much of their therapeutic effect is mediated not by the cells themselves but by exosomes, which are extracellular vesicles (EVs). Exosomes efficiently deliver molecules needed for regeneration, such as nucleic acids and proteins, to target cells, promoting cell proliferation and angiogenesis. This is expected to accelerate wound healing and minimize the formation of scars.
Therapies based on MSCs and exosomes may offer an innovative approach to severe wounds that have been difficult to treat with conventional methods. Research toward clinical application is advancing, aiming to shorten healing time and achieve functional skin regeneration.
【Reference】
Journal: Tissue Cell (2026)
DOI: 10.1016/j.tice.2025.103201