Tag
3 #lipid nanoparticle
Drug Delivery
2026-10-08
The mRNA vaccine's 'booster' was not the contents but the container — the ionizable lipid hits TLR4 and sets off innate immunity
mRNA vaccines contain no adjuvant, yet immunity is strong. A 2025 npj Vaccines study: empty LNPs with no mRNA switched on innate immunity via the ionizable lipid and TLR4, and adding mRNA added nothing.
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Drug Delivery
2026-10-08
Counting mRNA-Carrying Lipid Nanoparticles One at a Time — The Average Load Was 2.8 mRNA Molecules, and 8 Out of 10 Particles Were Running 'Empty'
The 'encapsulation efficiency 94%' on an LNP spec sheet counts mRNA, not particles. A 2022 Nature Communications paper counted one particle at a time: mean 2.80 copies, mode 2, 77% carrying none.
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Drug Delivery
2026-10-03
Giving a drug-carrying lipid nanoparticle (LNP) an address label: don't stick it on the surface, insert it afterwards. Before or after dialysis, the particle's fate changed
A 2022 formulation paper tackles one thing: how to give an LNP its address label. Direct surface coupling swelled the particles to 153 nm; inserting after dialysis held them to 93 nm.
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