Tag
2 #miRNA
MSC Exosome
2026-09-16
Doubling the Injected Dose Did Not Improve Recovery — In Spinal Cord–Injured Rats, What Was Deciding Whether the Exosomes Worked
Small extracellular vesicles (sEVs) from human bone marrow MSCs, delivered to spinal cord–injured rats either as daily injections or as a continuous infusion from an osmotic pump. At the same total dose of 9.2 μg, only the group infused continuously for six days climbed to a BBB score of 12.9±0.9, while the same amount split into six injections stalled at 8.6±0.9. Doubling the injected dose changed nothing against the three-day schedule, and collagen 1 at the lesion was also significantly lower under continuous infusion than under injections of the same total amount. Dr. Exotaro reads a preclinical rat study.
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MSC Exosome
2026-09-09
Rewriting the Blueprint of the Cell That Makes the Sac, Not the Sac Itself — But This Review Prints Not a Single p-Value, Dose, or n
A review that takes on insulin resistance with gene-modified MSC exosomes loaded with miR-21 and SIRT3. But it contains not a single experiment by the authors themselves, prints not one p-value, dose, or n, and cites not one clinical trial targeting insulin resistance in humans. Dr. Exotaro reads through a review that stays preclinical.
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