Tag
2 #mitochondria
MSC Exosome
2026-09-09
Rewriting the Blueprint of the Cell That Makes the Sac, Not the Sac Itself — But This Review Prints Not a Single p-Value, Dose, or n
A review that takes on insulin resistance with gene-modified MSC exosomes loaded with miR-21 and SIRT3. But it contains not a single experiment by the authors themselves, prints not one p-value, dose, or n, and cites not one clinical trial targeting insulin resistance in humans. Dr. Exotaro reads through a review that stays preclinical.
解説を読む →
Neuroscience
2026-07-25
The Mitochondria Were Broken, Yet ATP Went Up — What Was Happening in the Spinal Cord of a Frog That Cannot Regenerate
A tadpole whose spinal cord is severed will regenerate; after metamorphosis, the same frog cannot, and its response closely resembles that of humans. In Chile, Dr. Slater and colleagues showed that on the non-regenerating side, mitochondria swell by day 6 after injury, cristae turn into vesicles, and the respiratory enzyme COX shuts down. Yet ATP did not fall — it rose. Genes for glycolysis and genes that mobilize fat were both switched on. That said, the extra ATP may simply have leaked out of damaged tissue. Dr. Exotaro reads this preclinical frog study.
解説を読む →