Tag
2 #BDNF
Neuroscience
2026-08-01
The 'Neurotrophic Factors' Linking Stroke, Traumatic Brain Injury, and Neurodegeneration — Why Drugs That Should Work Can't Reach the Brain
Stroke, TBI, and Alzheimer's/Parkinson's differ in cause but converge on the same breakdown pathways. Why don't NGF and BDNF work in humans? A Russian team reads the delivery barrier from six trials.
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Neuroscience
2026-07-12
Rewiring the Link Between "Muscle" and "Brain"—Cognitive-Motor Integration (CMI), the Key to Reclaiming Cognition Through Exercise in Neurological Disease
Exercise reaches the brain through peripheral signals—BDNF, lactate, immune and vascular messengers. But a biomarker "moving" is not the same as cognition returning. An Italian neurorehabilitation team offers an integrative model: the biological effects of exercise become clinically meaningful only when they couple to attention-demanding movement and surface as a behavior called cognitive-motor integration (CMI). Exotaro unpacks a review that surveys the differences across stroke, Parkinson's, MS, and TBI, and how to deploy VR, robots, and wearables.
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