Tag
3 #drug delivery
Drug Delivery
2026-10-03
Giving a drug-carrying lipid nanoparticle (LNP) an address label: don't stick it on the surface, insert it afterwards. Before or after dialysis, the particle's fate changed
A 2022 formulation paper tackles one thing: how to give an LNP its address label. Direct surface coupling swelled the particles to 153 nm; inserting after dialysis held them to 93 nm.
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Neuroscience
2026-08-01
The 'Neurotrophic Factors' Linking Stroke, Traumatic Brain Injury, and Neurodegeneration — Why Drugs That Should Work Can't Reach the Brain
Stroke, TBI, and Alzheimer's/Parkinson's differ in cause but converge on the same breakdown pathways. Why don't NGF and BDNF work in humans? A Russian team reads the delivery barrier from six trials.
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Extracellular Vesicles
2026-07-06
Turning the "Natural Capsules" Secreted by Stem Cells into Drug Carriers: Engineering and Clinical Safety of MSC-Derived Extracellular Vesicles (EVs)
MSC-derived extracellular vesicles are biocompatible, low-immunogenicity 'natural nanocapsules.' This review maps six strategies to engineer them into drug carriers and their clinical safety data.
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