Tag
3 #exosomes
Clinical
2026-08-01
Knee Joint Injections: Which One Actually Works?—From Steroids to Exosomes, Decoding 9 Treatments at the Molecular Level
A narrative review of knee injections, corticosteroids to exosomes: an RCT tying repeated triamcinolone to cartilage loss, and the evidence-maturity gap across PRP, orthobiologics, MSCs, exosomes.
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MSC Exosome
2026-07-12
Taking on Parkinson's Disease and the "Runaway Immune System of the Brain"—How an lncRNA Carried by Deep-Nasal Stem-Cell Exosomes Rewires Microglial Glucose Metabolism
In Parkinson's disease, the brain's immune cells—microglia—switch into a 'combat mode that guzzles sugar,' damaging neurons through inflammation. A research team in Haikou, China, showed that lncA2M-AS1, a long non-coding RNA (lncRNA) carried by exosomes from olfactory mucosa-derived mesenchymal stem cells (OM-MSC), calms microglial metabolism and suppresses neuroinflammation through two switches, CFL1 and ROCK1. Exotaro walks through this preclinical study in mice and cultured cells.
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Extracellular Vesicles
2026-07-12
Confronting Diabetes's "Wounds That Won't Heal": Delivering Blood-Vessel-Summoning Exosomes with a Dissolving Microneedle
Diabetic wounds pit impaired angiogenesis against chronic inflammation. A team engineered bFGF-loaded, RGD-targeted M2 exosomes, delivered deep by a dissolving microneedle, to speed healing in diabetic mice.
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