Tag
3 #extracellular vesicles
Extracellular Vesicles
2026-08-03
IL-10 Becomes Harder to Break Down When Loaded onto Extracellular Vesicles — But Naïve Vesicles, With No Gene Added, Calmed Inflammation Too
IL-10, the cytokine that calms inflammation, never quite became a drug: it is unstable and clears from the body fast. A Michigan State University team harvested extracellular vesicles from cells made to overexpress IL-10 with minicircle DNA, and shows they are more stable than recombinant IL-10 and quiet inflammatory macrophages. But naïve vesicles, with no IL-10 gene introduced, worked too. Every experiment is in cultured cells.
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Extracellular Vesicles
2026-07-20
When the obesity-stressed pancreas quietly calls the stem cells next door for backup: how miR-151 vesicles from beta cells turn mesenchymal stem cells into helpers
As obesity drags on, pancreatic beta cells multiply and work harder to hold off diabetes (beta cell compensation). A team at China Pharmaceutical University shows that in this emergency, beta cells release extracellular vesicles (sEV) loaded with miR-151 and turn nearby mesenchymal stem cells (MSC) into helpers. Freed from the KLF9 brake, the MSCs proliferate and secrete WNT to support beta cells. Dr. Exotaro unpacks this cell-and-mouse preclinical study.
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Extracellular Vesicles
2026-07-06
Turning the "Natural Capsules" Secreted by Stem Cells into Drug Carriers: Engineering and Clinical Safety of MSC-Derived Extracellular Vesicles (EVs)
MSC-derived extracellular vesicles are biocompatible, low-immunogenicity 'natural nanocapsules.' This review maps six strategies to engineer them into drug carriers and their clinical safety data.
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