Cell Biology

This study reveals that the nascent polypeptide-associated complex (NAC) is a multifaceted regulator coordinating translation elongation, co-translational folding, and organelle targeting.

This study reveals that DNA-damaging chemotherapy dramatically alters the composition and function of cardiac-resident macrophages, with monocyte-derived macrophages conferring cardioprotection.

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration, published in Nature Neuroscience.

This study identifies blood biomarkers of multimorbidity in older adults and clarifies their shared and specific features, linking 54 biomarkers to multimorbidity indicators in two cohorts.

This study reveals a previously unknown macrophage population, the "adenophages," in exocrine glands such as the salivary glands, maintained by GM-CSF from group 2 innate lymphoid cells (ILC2s).

Why does this research matter? Our bodies are made up of tens of trillions of cells. At the end of their lifespan or when infected, these cells carry a built-in mechanism to end their own lives.

Q&A on a study showing TLR4 deficiency suppresses necroptosis (RIPK3/MLKL) and NFκB signaling after spinal cord injury (SCI), cutting chronic inflammation and aiding recovery.

Single-nucleus RNA sequencing of adult zebrafish over six weeks reveals how neurogenesis and neuronal plasticity cooperate to drive spinal cord repair, identifying injury-responsive iNeurons.

A single-cell study integrating morphological and lipidomic profiling of MSCs, showing these features can distinguish functional subpopulations induced by immune stimulation.

Non-classical monocytes are supported by the entire vascular tree. Non-classical monocytes have the support of the whole vascular tree – Nature Reviews I

Flow cytometry is a popular technique for analyzing cell characteristics and function, especially when cells come directly from in vivo samples. However, this approach comes with several constraints.

The endosomal recycling pathway and autophagy are two distinct cellular processes that provide different mechanisms for maintaining cellular homeostasis. Their main differences are explained below.

Autophagy plays a role second only to the ubiquitin-proteasome system in cellular degradation, delivering unwanted or harmful material to the lysosome for breakdown.

After spinal cord injury, scar tissue forms at the injury site. It is composed of a glial component and a fibrin component. The glial scar is characterized by extensive astrocyte proliferation.

Autophagy is the process by which cells degrade and recycle damaged or dysfunctional components and unwanted proteins. It supports cellular homeostasis and is linked to disease and aging.

Microautophagy is a cellular self-digestion process that degrades and recycles cellular components directly through the lysosomal membrane. Here we explain its mechanisms and roles.

In IPA (Ingenuity Pathway Analysis), the P-value is obtained through statistical analysis. It is a metric that evaluates whether observed data is statistically significant versus random conditions.

You may have heard the term "Fourier transform" in math or engineering. It is a mathematical method widely used in signal processing, image analysis, and data compression. But what exactly is it?

About CRISPR — What is CRISPR? If you are exploring the fascinating world of genetics and biotechnology, you have probably heard the term CRISPR. But what does it mean?

The use of statistical tools is widespread across many fields, including biology. One such important statistical metric is the Z-score.

An endosome is a small membranous vesicle in the cytoplasm of eukaryotic cells. It acts as an intermediate in the cell's transport system, sorting and recycling internalized substances.