What Are Exosomes?
What are Extracellular Vesicles and Exosomes (Basics, Classification, Properties)
An introductory chapter on the definition, classification, and basic biology of extracellular vesicles (EVs) and exosomes.
Biogenesis and Release of Exosomes (Endosome, MVB, ESCRT)
Explains the molecular machinery by which exosomes form and are released from endosomes via multivesicular bodies (MVBs).
Cargo of Extracellular Vesicles (Proteins, Lipids, RNA)
Covers the protein, lipid, and RNA cargo carried by extracellular vesicles (EVs) and how it is sorted.
Isolation, Identification, and Analysis Technologies
Introduces the techniques and instruments used to isolate, recover, identify, and analyze extracellular vesicles (EVs).
Biology and Formulation of MSC-Derived Exosomes
Covers the biology of mesenchymal stem cell (MSC)-derived exosomes and topics in their formulation and quality.
- Are MSC-Exosomes Attacked by Immune Cells?
- Molecular Mechanism by Which Cortical Actin Depolymerization in 3D Culture Enhances MSC-Derived Exosome Secretion and Therapeutic Efficacy
- Investigating MSC (mesenchymal stem cell) Potency Metrics by Integrating Imaging Modalities with Lipidomic Analysis
- The Truth About Exosome Products: Efficacy, Safety, and a Look to the Future
- Comparative Evaluation of Storage Conditions for Extracellular Vesicles: Impact on Function and Therapeutic Applications
Regenerative Medicine and Tissue Repair (Spinal Cord, Skin, Bone, etc.)
Gathers research on tissue repair and regenerative medicine of the spinal cord, skin, bone, and more using exosomes and stem cells.
- The Effect of Exosomes on Spinal Cord Injury
- Continuous Infusion of Human MSC-Derived Exosomes (sEV) Enhances Motor Recovery in Spinal Cord Injury: How You Deliver Them Matters More Than the Total Dose
- A New Possibility for Improving Body Growth and Motor Function After Spinal Cord Injury: Intervention with Extracellular Vesicles (Exosomes) Derived from Bone Marrow Mesenchymal Stem Cells
- The Power of Dental Stem Cells! The Potential of "Exosomes" to Heal Spinal Cord Injury
- Toward the dream of skin regeneration! The future of wound treatment opened up by stem cells and exosomes
- Single-cell analysis of innate spinal cord regeneration: a study using a zebrafish transection model
- TLR4 Knockout Modulates Cytokine and Extracellular Matrix Expression in Chronic Spinal Cord Injury, Improving Secondary Damage and Functional Recovery
- Spinal Cord Injury: Does the Immune Response Differ by Age!?
Brain, Neuroscience, and Extracellular Vesicles
Covers brain and nervous-system science and the role of extracellular vesicles (EVs) in neurodegeneration and neural repair.
- The primary motor cortex does not govern movement alone!?
- Cutting-Edge Neuroscience: Dissecting the Mouse Prefrontal Cortex
- The Role of Extracellular Matrix Degradation in Supporting Synaptic Plasticity During Brain Development
- Microglial TGFβ signaling in the spinal dorsal column maintains resilience to age-associated myelin degeneration
- New Hope for Alzheimer's Disease: Exploring the VCAM1–ApoE Pathway and Advanced Protein Interaction Tools
- GLP-1 Receptor Agonists: A New Hope for Alzheimer's Disease Treatment? Mechanisms and Clinical Significance from Multiple Perspectives
- A Future Drug to Protect the Brain: How iPSC-Derived Extracellular Vesicles Prevent the Overwork Death of Neurons
- The Secret of Steering the Brain's Regeneration Factory: How L-Myc and the Cell's Courier Service (EVs) Unlock the Diversity of Neural Stem Cells
- Astrocyte-Derived Exosome-Mediated Transport of Rps6 Promotes Local Translation and Synaptic Function in Alzheimer's Disease Model Neurons
- [Articles] Collateral-based selection for endovascular treatment of acute ischaemic stroke in the late window (MR CLEAN-LATE): 2-year follow-up of a phase 3, multicentre, open-label, randomised controlled trial in the Netherlands
Cancer and Extracellular Vesicles
Explains how extracellular vesicles (EVs), stem cells, and immunity are involved in cancer progression, metastasis, and therapy.
- Hope for Liver Cancer Treatment? The Remarkable Power of Umbilical Cord Stem Cells
- Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC
- The Future of Testicular Cancer Treatment: A New Strategy in Which Immune Cells and Stem Cells Break Through Refractory Cancer
- Bispecific Exosome Therapy: An Innovative Approach to Immune Checkpoint Inhibitor-Resistant Melanoma Metastasis
- The Vicious Cycle of Prostate Cancer Bone Metastasis: Molecular Mechanisms by Which Cancerized Osteoclast-Derived Exosomes Drive Inflammatory Osteolysis and Tumor Progression
Clinical Medicine, Biomarkers, and Therapy
Surveys current clinical-medicine topics including stem-cell therapy, clinical trials, and biomarkers.
- Stem Cell Clinical Science: Introduction.
- An Overview of Stem Cell Therapy in Japan: Current Status, Risks, and Future Prospects
- A new treatment for hemophilia: from the Lancet
- What Is ATTR Cardiac Amyloidosis? A Thorough Explanation of the Efficacy and Safety of the Latest Treatment, Patisiran — From the Results of the NEJM APOLLO-B Trial
- TAVR (Transcatheter Aortic Valve Replacement): An Innovative Advance in Heart Disease Treatment
- Blood Biomarkers of Multimorbidity: Probing the Mechanisms of Aging Through Shared and Specific Features
Foundations of Cell Biology (Autophagy, Macrophages, etc.)
Learn the cell-biology foundations behind extracellular vesicles, including autophagy, macrophages, and monocytes.
- What Is Autophagy?
- What Is Microautophagy
- The Difference Between the Endosomal Recycling Pathway and Autophagy
- What Is Fibronectin?
- NAC: A Multifaceted Regulator of Nascent Polypeptide Chains That Senses the Ribosomal Tunnel and Controls Chaperone Function
- A paper showing that microglia influence neuronal autophagy
- Pathways Related to Autophagy in Microglia
- Non-classical monocytes have the support of the whole vascular tree
- A Newcomer Macrophage Hiding in Exocrine Glands, the "Adenophage": How ILC2s and GM-CSF Weave the Secret of Maintaining Tissue Function
- Chemotherapy Remodels Cardiac Macrophages: A New Path to Cardioprotection
- [Research Note] Network Analysis of 5 Key miRNAs Controlling Macrophages and Their "Converging Target Proteins"
- Stop the Cell's "Rusting Death"! How Ferroptosis Inhibitors Open a New Frontier in Treating Intractable Diseases
Research Toolbox (Statistics, Analysis, AI Tools)
A collection of research methods including statistics, omics analysis, flow cytometry, and AI tools.
- Talking with papers!? An introduction to AI tools
- What Is CRISPR Library Screening?
- Understanding the Z-Score in Biology
- What Is the Fourier Transform?
- How is the P-value calculated in IPA pathway analysis?
- Flow Cytometry Analysis: Constraints and Caveats of Isolating Cells from In Vivo Samples
- Large-scale plasma proteomics comparisons through genetics and disease associations
- Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
Conferences, Reviews, and the Frontier
Surveys the frontier of extracellular vesicle (EV) research through international conferences such as ISEV and review articles.